Endocrine Abstracts

We believe this is the first case report of anunusual presentation of hypercalcemia due to sarcoidosis mimicking metastatic colon carcinoma. A 68 year old lady with a background history of pancolectomy and neoadjuvant chemotherapy for Duke C1 rectal carcinoma under surveillance, ulcerative colitis, type 2 diabetes mellitus presented to the clinic with hypercalcemia with low parathyroid hormone (PTH) and symptoms of tiredness. Her blood test showed Adj Ca of 2.8 mmol/l, PTH &#6...

A 74-year-old man was admitted to hospital with diarrhoea, vomiting, abdominal and lower back pain and reduced urine output. Past medical history included hypertension, angina and hypercholesterolemia. Initial diagnosis was campylobacter gastroenteritis and managed accordingly.Two weeks later patient developed fatiguability, exertional dyspnoea and joint pain with persistently high creatinine. CT thorax/abdomen/pelvis was performed...

A 74-year-old man was admitted to hospital with diarrhoea, vomiting, abdominal and lower back pain and reduced urine output. Past medical history included hypertension, angina and hypercholesterolemia. Initial diagnosis was campylobacter gastroenteritis and managed accordingly.Two weeks later patient developed fatiguability, exertional dyspnoea and joint pain with persistently high creatinine. CT thorax/abdomen/pelvis was performed...

Background: Low testosterone in men is associated with increase in all-cause and cardiovascular mortality. There is a high prevalence of hypogonadism in men with type 2 diabetes and testosterone replacement therapy (TRT) improves cardiovascular risk. However there is no published data regarding mortality in these patients in relation to testosterone levels, and the long term effect of TRT on mortality.Aim: We report a 6 year follow-up study examining the...

Background: In men with type 2 diabetes there is high prevalence of low levels of testosterone. There is accumulating evidence that low testosterone levels are associated with greater morbidity and mortality. There is no published data regarding mortality among men with type 2 diabetes in relation to testosterone levels.Aim: We report preliminary findings from our 4 to 7 years follow up study to examine the effect of baseline testosterone on all cause mo...

We describe a patient who was treated for hypercalcaemia with inadvertent ramifications. A 59 year old gentleman with a background history of chronic kidney disease stage (CKD) 4, type 2 diabetes mellitus, hypertension, congestive cardiac failure and bilateral lower limb below knee amputations, presented with hypercalcemia of 3.30 mmol/l (reference range 2.20–2.60) and suppressed PTH at 12 ng/l (reference range 15–65), from a previously raised PTH level of 162 due to...

Introduction: Low testosterone levels are associated with cardiovascular morbidity and an increased risk of non-alcoholic steatohepatitis (NASH). NASH is closely associated with insulin resistance and atherosclerosis.AIM: We studied the effect of long-term testosterone replacement therapy (TRT) on liver function and cardiovascular risk factors in hypogonadal men.Method: Retrospective audit of 308 hypogonadal men receiving TRT as in...

Background: There is a close association between low testosterone and metabolic syndrome. Testosterone replacement therapy (TRT) has beneficial effects on cardiovascular (CV) risk factors in men with hypogonadism.Aim: This is a retrospective audit of CV parameters in hypogonadal men treated with testosterone undecanoate (Nebido) in standard clinical practice.Methods: Patients with hypogonadism on testosterone undecanoate injections...

Hypogonadism is more prevalent in populations with type 2 diabetes (T2D) and/or cardiovascular disease (CVD) and is associated with increase in all-cause and CVD mortality. Testosterone replacement therapy (TRT) improves visceral adiposity, insulin resistance, glycemia, lipids inflammatory cytokines and cardiac ischaemia. The long-term safety of TRT in men with CVD and/or T2D is not known and the British National formulary advises use with caution these groups.<p class="ab...

We would like to present an interesting unusual case of fluoroquinolone induced hypoglycaemia. As per FDA Adverse Event reporting System and medical literature published between 1987–2017, fluoroquinolones are said to have caused about 67 cases of life-threatening hypoglycaemic coma including 13 deaths and 9 permanent disabling injuries, most cases were associated with levofloxacin. Its hypoglycaemic effect is more common in elderly population who are on oral hypoglycaemi...